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ea0090oc7.1 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

Mills Edouard G , Swedrowska Magda , Delli Virginia , Chachlaki Konstantina , Sergio Mauro , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie , Muzi Beatrice , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander , Dhillo Waljit

Background: Kisspeptin is a critical activator of hypothalamic GnRH neurons and is essential for reproductive health. Emerging data reveals that kisspeptin-based therapeutics have substantial potential to treat reproductive, psychosexual and bone disorders. However, current delivery is limited to the subcutaneous or intravenous routes, presenting barriers to development. Alternative routes of administration would overcome this and capitalise on the benefits of kisspeptin-based...

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Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

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